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Recurrent respiratory papillomatosis (RRP)

What causes RRP?

RRP is caused by HPV 6 or 11. HPV is a viral infection that can cause growths in the airway. This can result in growths that have traditionally been removed by surgery. PAPZIMEOS is a targeted treatment that works on the root cause of RRP to fight HPV and can help some people need fewer surgeries.

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How is RRP diagnosed?

RRP is often diagnosed when an ENT looks at your throat and sees papillomas, or growths. If they think it is RRP, they will take a sample of the growth to help confirm that it is associated with RRP.

See how RRP used to be treated >

What is the first-line recommended treatment for RRP?

Experts supported by the RRP Foundation recommend immunotherapy that targets cells infected with HPV as the first medical treatment after a procedure to remove any visible growths. PAPZIMEOS may be the right treatment choice for you.

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Will removing papillomas with surgery stop them from coming back?

While surgery can remove the papillomas and ease the symptoms of RRP, it may provide only temporary relief because it does not address the root cause of RRP: chronic infection with HPV 6 or 11. The papillomas may grow back again and the symptoms may reappear, requiring repeated surgeries over time.

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What resources are available to help me talk to my doctor about treatment for RRP?

Review this Discussion Guide to help find answers to the questions and concerns that you may have.

Read the Discussion Guide >

PAPZIMEOS

What is PAPZIMEOS?

PAPZIMEOS is an immunotherapy that is recommended as a first-line treatment for adults with RRP. It is given as 4 injections just under the skin over 12 weeks. PAPZIMEOS may be the right treatment for you. Please see full Prescribing Information.

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How does PAPZIMEOS work in RRP?

PAPZIMEOS is the first FDA-approved treatment that targets the root cause of RRP in adults. PAPZIMEOS is a type of immunotherapy designed to train your immune system to eliminate cells infected with HPV 6 or 11.

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How can PAPZIMEOS help treat RRP?

Papillomas may come back after surgery in some patients, and PAPZIMEOS helped some patients remain surgery free for 3 years. See the full trial results for people with RRP treated with PAPZIMEOS.

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When do I start treatment for RRP with PAPZIMEOS?

PAPZIMEOS is approved for adults with RRP after your doctor removes any visible papillomas. Find out how a treatment of 4 injections over 12 weeks can help you manage your RRP.

Learn more about starting PAPZIMEOS >

How long does treatment take with PAPZIMEOS?

The PAPZIMEOS Treatment Plan takes 3 months. It is given as 4 injections just under the skin. See what you may expect from treatment with PAPZIMEOS.

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Where can I go to get my PAPZIMEOS treatment?

Look up sites near you where you may be able to receive PAPZIMEOS.

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How is PAPZIMEOS the same as or different than other immunotherapies?

PAPZIMEOS is:
PAPZIMEOS is an immunotherapy
This means that PAPZIMEOS trains your immune system to eliminate cells infected with HPV. Other immunotherapies teach the body to do other things
PAPZIMEOS is a recommended first-line treatment
Experts supported by the RRP Foundation recommend PAPZIMEOS for adults with RRP
PAPZIMEOS is injected just under the skin
This is known as a subcutaneous injection or a shot that is given in the upper arm or thigh
PAPZIMEOS is given as 4 injections over 12 weeks
The PAPZIMEOS Treatment Plan* is designed to be fully given over 3 months
*Before your first dose, your doctor will remove any papillomas they can see. You may need another surgery before your third and/or fourth doses.
PAPZIMEOS is not:
PAPZIMEOS is not a treatment for other diseases
While immunotherapies may be used in different kinds of diseases, PAPZIMEOS is indicated only for adults with RRP due to HPV 6 or 11
The PAPZIMEOS study is not done following up with patients
PAPZIMEOS was approved for use in adults with RRP based on results that followed patients for up to 2 years. Follow-ups are still ongoing
PAPZIMEOS is not an infusion
An infusion is a way to help put fluids and medications into the bloodstream. Some infusions may take a longer time and must be given directly into a vein
PAPZIMEOS is not a surgery
Your doctor will remove any visible papillomas before your first dose of PAPZIMEOS. You may need another surgery before your third and/or fourth doses

Have you seen how PAPZIMEOS has helped some people need fewer surgeries after completing treatment?

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Papzimeos SUPPORT and resources

What resources can help me talk to my doctor about PAPZIMEOS and RRP?

The PAPZIMEOS discussion points can help you find information to make a decision about a treatment approach that works for you and your RRP.

See the questions >

What is Papzimeos SUPPORT?

Papzimeos SUPPORT helps provide information about your treatment journey with PAPZIMEOS for RRP. Learn more about understanding coverage, financial assistance, and the Copay Program. You can call Papzimeos SUPPORT at (866) 827-8180, Monday to Friday, 8 am to 8 pm ET.

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Will PAPZIMEOS be covered by my insurance, and what financial assistance options are available?

The Papzimeos SUPPORT Copay Program may help eligible people with RRP pay as little as $0 out of pocket for PAPZIMEOS. Eligible people must have commercial insurance and be enrolled in the Copay Program. Speaking with the doctor's office and Papzimeos SUPPORT can help answer questions you may have about coverage.

Terms and conditions apply.

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Learn more about RRP and PAPZIMEOS

See the Discussion Guide

Looking for a treatment site to receive PAPZIMEOS?

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Get more information about your treatment journey with PAPZIMEOS

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What is PAPZIMEOS?

PAPZIMEOS is a type of immunotherapy used to treat a condition called recurrent respiratory papillomatosis (RRP) in adults.

Important Safety Information

What is the most important information I should know about PAPZIMEOS?

Some people may have a reaction to the shot. Signs and symptoms may include redness, pain, swelling, itching, or warmth where the shot was given. After your first treatment, your healthcare provider will watch you for at least 30 minutes to make sure you're feeling okay.

Please contact your doctor immediately if you develop an infection, the reaction to your shot worsens, or you experience any of the below symptoms, which may indicate a systemic allergic reaction:

  • Difficulty breathing
  • Widespread rash
  • Facial swelling

Thrombotic events (blood clots that block your blood vessels) may occur after your PAPZIMEOS shot. Please notify your doctor immediately if you have the following symptoms:

  • Shortness of breath
  • Chest pain
  • Leg swelling
  • Persistent abdominal pain
  • Severe or persistent headaches
  • Blurred vision

What should I know before taking PAPZIMEOS?

Before taking PAPZIMEOS, tell your healthcare provider about all of your medical conditions, including:

  • If you are pregnant or plan to become pregnant because it is not known if PAPZIMEOS will harm the unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is unknown if PAPZIMEOS is present in breast milk, or how it affects the breastfeeding child or milk production. Talk to your healthcare provider about the best way to feed your baby during treatment with PAPZIMEOS.

What are the most common side effects of PAPZIMEOS?

The most common side effects include:

  • Pain, redness, or swelling where the shot was given
  • Feeling tired
  • Chills
  • Fever
  • Muscle aches
  • Nausea (feeling sick)
  • Headache
  • Increased heart rate
  • Diarrhea
  • Vomiting
  • Sweating a lot

These are not all of the possible side effects of PAPZIMEOS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also report side effects to Precigen, Inc. at 1-855-PGE-NRRP (1-855-743-6777).

Please see full Prescribing Information.

What is PAPZIMEOS?

PAPZIMEOS is a type of immunotherapy used to treat a condition called recurrent respiratory papillomatosis (RRP) in adults.

Important Safety Information

What is the most important information I should know about PAPZIMEOS?

Some people may have a reaction to the shot. Signs and symptoms may include redness, pain, swelling, itching, or warmth where the shot was given. After your first treatment, your healthcare provider will watch you for at least 30 minutes to make sure you're feeling okay.

What is PAPZIMEOS?

PAPZIMEOS is a type of immunotherapy used to treat a condition called recurrent respiratory papillomatosis (RRP) in adults.

Important Safety Information

What is the most important information I should know about PAPZIMEOS?

Some people may have a reaction to the shot. Signs and symptoms may include redness, pain, swelling, itching, or warmth where the shot was given. After your first treatment, your healthcare provider will watch you for at least 30 minutes to make sure you're feeling okay.

Please contact your doctor immediately if you develop an infection, the reaction to your shot worsens, or you experience any of the below symptoms, which may indicate a systemic allergic reaction:

  • Difficulty breathing
  • Widespread rash
  • Facial swelling

Thrombotic events (blood clots that block your blood vessels) may occur after your PAPZIMEOS shot. Please notify your doctor immediately if you have the following symptoms:

  • Shortness of breath
  • Chest pain
  • Leg swelling
  • Persistent abdominal pain
  • Severe or persistent headaches
  • Blurred vision

What should I know before taking PAPZIMEOS?

Before taking PAPZIMEOS, tell your healthcare provider about all of your medical conditions, including:

  • If you are pregnant or plan to become pregnant because it is not known if PAPZIMEOS will harm the unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is unknown if PAPZIMEOS is present in breast milk, or how it affects the breastfeeding child or milk production. Talk to your healthcare provider about the best way to feed your baby during treatment with PAPZIMEOS.

What are the most common side effects of PAPZIMEOS?

The most common side effects include:

  • Pain, redness, or swelling where the shot was given
  • Feeling tired
  • Chills
  • Fever
  • Muscle aches
  • Nausea (feeling sick)
  • Headache
  • Increased heart rate
  • Diarrhea
  • Vomiting
  • Sweating a lot

These are not all of the possible side effects of PAPZIMEOS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also report side effects to Precigen, Inc. at 1-855-PGE-NRRP (1-855-743-6777).

Please see full Prescribing Information.

ENT=ear, nose, and throat specialist; HPV=human papillomavirus.