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Get ready to start PAPZIMEOS

A man throwing broken record of RRP surgery out of a window.
Not an actual patient.

One year after completing treatment with PAPZIMEOS in a clinical study, 51% of patients (18 of 35) remained surgery free.

You may be able to

Throw out the broken record of RRP

PAPZIMEOS is recommended as a first-line treatment for adult patients with RRP.

PAPZIMEOS was designed to train your immune system to eliminate cells infected with HPV 6 or 11.

Talk to your doctor to see if PAPZIMEOS may be right for you.

The PAPZIMEOS Treatment Plan is designed to train your immune system with 4 doses over 3 months*

PAPZIMEOS is injected just under the skin (a subcutaneous injection) and can only be given by a healthcare professional.

Because PAPZIMEOS is a specialty medicine, your ENT may need to work with other specialists and facilities that can help store and give PAPZIMEOS.

*Before your first dose, your doctor will remove any papillomas they can see. You may need another surgery before your third and/or fourth doses.

Looking for a treatment site to receive PAPZIMEOS?

Find a site near meSee the PAPZIMEOS Discussion Guide

The PAPZIMEOS Treatment Plan is designed to set you up for success

Starting treatment with a clear airway is crucial for lasting results. So, before your first dose, your doctor will remove visible papillomas (growths). Your doctor may also decide to remove visible papillomas before your third and/or fourth doses. Think of it as keeping the slate clean.

PAPZIMEOS is given in 4 doses over 12 weeks

WEEK
0
CLEAR

Dose 1 starts with a clear airway and trains your immune system to find cells infected with HPV 6 or 11

WEEK
2
CONTINUE

Dose 2 is designed to help your immune system continue learning how to eliminate HPV cells

WEEK
6
CARRY ON

Dose 3 is designed to help your immune system carry on learning

WEEK
12
COMPLETE

Dose 4 is the final dose in your PAPZIMEOS Treatment Plan

  • The second dose should be given no less than 11 days after the first dose
  • After your first dose, your healthcare provider will watch you for at least 30 minutes to make sure you're feeling okay

Some people may have a reaction to the injection. Signs and symptoms may include redness, pain, swelling, itching, or warmth where the shot was given.

Results may vary.

Learn more about RRP and how PAPZIMEOS may be able to help.

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Patient Brochure

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What is PAPZIMEOS?

PAPZIMEOS is a type of immunotherapy used to treat a condition called recurrent respiratory papillomatosis (RRP) in adults.

Important Safety Information

What is the most important information I should know about PAPZIMEOS?

Some people may have a reaction to the shot. Signs and symptoms may include redness, pain, swelling, itching, or warmth where the shot was given. After your first treatment, your healthcare provider will watch you for at least 30 minutes to make sure you're feeling okay.

Please contact your doctor immediately if you develop an infection, the reaction to your shot worsens, or you experience any of the below symptoms, which may indicate a systemic allergic reaction:

  • Difficulty breathing
  • Widespread rash
  • Facial swelling

Thrombotic events (blood clots that block your blood vessels) may occur after your PAPZIMEOS shot. Please notify your doctor immediately if you have the following symptoms:

  • Shortness of breath
  • Chest pain
  • Leg swelling
  • Persistent abdominal pain
  • Severe or persistent headaches
  • Blurred vision

What should I know before taking PAPZIMEOS?

Before taking PAPZIMEOS, tell your healthcare provider about all of your medical conditions, including:

  • If you are pregnant or plan to become pregnant because it is not known if PAPZIMEOS will harm the unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is unknown if PAPZIMEOS is present in breast milk, or how it affects the breastfeeding child or milk production. Talk to your healthcare provider about the best way to feed your baby during treatment with PAPZIMEOS.

What are the most common side effects of PAPZIMEOS?

The most common side effects include:

  • Pain, redness, or swelling where the shot was given
  • Feeling tired
  • Chills
  • Fever
  • Muscle aches
  • Nausea (feeling sick)
  • Headache
  • Increased heart rate
  • Diarrhea
  • Vomiting
  • Sweating a lot

These are not all of the possible side effects of PAPZIMEOS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also report side effects to Precigen, Inc. at 1-855-PGE-NRRP (1-855-743-6777).

Please see full Prescribing Information.

What is PAPZIMEOS?

PAPZIMEOS is a type of immunotherapy used to treat a condition called recurrent respiratory papillomatosis (RRP) in adults.

Important Safety Information

What is the most important information I should know about PAPZIMEOS?

Some people may have a reaction to the shot. Signs and symptoms may include redness, pain, swelling, itching, or warmth where the shot was given. After your first treatment, your healthcare provider will watch you for at least 30 minutes to make sure you're feeling okay.

What is PAPZIMEOS?

PAPZIMEOS is a type of immunotherapy used to treat a condition called recurrent respiratory papillomatosis (RRP) in adults.

Important Safety Information

What is the most important information I should know about PAPZIMEOS?

Some people may have a reaction to the shot. Signs and symptoms may include redness, pain, swelling, itching, or warmth where the shot was given. After your first treatment, your healthcare provider will watch you for at least 30 minutes to make sure you're feeling okay.

Please contact your doctor immediately if you develop an infection, the reaction to your shot worsens, or you experience any of the below symptoms, which may indicate a systemic allergic reaction:

  • Difficulty breathing
  • Widespread rash
  • Facial swelling

Thrombotic events (blood clots that block your blood vessels) may occur after your PAPZIMEOS shot. Please notify your doctor immediately if you have the following symptoms:

  • Shortness of breath
  • Chest pain
  • Leg swelling
  • Persistent abdominal pain
  • Severe or persistent headaches
  • Blurred vision

What should I know before taking PAPZIMEOS?

Before taking PAPZIMEOS, tell your healthcare provider about all of your medical conditions, including:

  • If you are pregnant or plan to become pregnant because it is not known if PAPZIMEOS will harm the unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is unknown if PAPZIMEOS is present in breast milk, or how it affects the breastfeeding child or milk production. Talk to your healthcare provider about the best way to feed your baby during treatment with PAPZIMEOS.

What are the most common side effects of PAPZIMEOS?

The most common side effects include:

  • Pain, redness, or swelling where the shot was given
  • Feeling tired
  • Chills
  • Fever
  • Muscle aches
  • Nausea (feeling sick)
  • Headache
  • Increased heart rate
  • Diarrhea
  • Vomiting
  • Sweating a lot

These are not all of the possible side effects of PAPZIMEOS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also report side effects to Precigen, Inc. at 1-855-PGE-NRRP (1-855-743-6777).

Please see full Prescribing Information.

ENT=ear, nose, and throat specialist; HPV=human papillomavirus; RRP=recurrent respiratory papillomatosis.