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Explore results from the PAPZIMEOS clinical study

Half of a group of people throwing out broken records of RRP surgery from a building with a close up of the broken record.

PAPZIMEOS may help people with RRP stop replaying surgery after surgery

PAPZIMEOS is recommended as a first-line treatment for adult patients with RRP.

1 year after treatment with PAPZIMEOS

(18 of 35)
Before your first dose, your doctor will remove any papillomas they can see. You may need another surgery before your third and/or fourth doses.

Over half had zero surgeries

Some people with RRP went from having at least 3 surgeries per year before taking PAPZIMEOS to 0 surgeries in the year after finishing treatment.

Graphic showing patients surgery free after 1 year.

Still surgery free

Most people surgery free at year 1 did not need surgery after 2 years (15 of 18).

Graphic showing patients surgery free after 2 years.

Surgery free for even longer

All people who were surgery free after 2 years (15 of 18) were still surgery free after a median follow-up of 3 years (range, 36-51 months).

Graphic showing patients surgery free after 3 years.

Still surgery free at 4 years

5 of the 18 people reached 4 years with no surgical interventions. The study is still ongoing.

5-year follow-up is ongoing

Among the 38 patients monitored for side effects in the clinical study, the most commonly reported side effects were pain, redness, or swelling where the shot was given, along with tiredness, chills, fever, muscle aches, nausea (feeling sick), headache, increased heart rate, diarrhea, vomiting, and sweating a lot.

Learn more about RRP and how PAPZIMEOS may be able to help.

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Patient Brochure

PAPZIMEOS reduced the overall number of surgeries

1 year after treatment with PAPZIMEOS

Some people with RRP went from having at least 3 surgeries a year before PAPZIMEOS to zero after finishing treatment. The 35 patients in the study who received the recommended dose had 152 surgeries total in the year before treatment—and only 46 in the year after.

A close up of a broken record of RRP surgeries cropped at the bottom.

Do you still have questions about RRP or the way PAPZIMEOS works?

See the Discussion Guide

The most common side effects of PAPZIMEOS included*:

  • Pain, redness, or swelling where the shot was given
  • Feeling tired
  • Chills
  • Fever
  • Muscle aches
  • Nausea (feeling sick)
  • Headache
  • Increased heart rate
  • Diarrhea
  • Vomiting
  • Sweating a lot

*Safety evaluation included all 38 people with RRP studied who received PAPZIMEOS. 35 people in the clinical study received the recommended dose of PAPZIMEOS.

No patients in the clinical trial had to stop taking PAPZIMEOS early due to side effects

Most adverse reactions happened after the first dose of PAPZIMEOS and usually lasted 1-3 days.

In people who took PAPZIMEOS, the most common adverse reactions were mild to moderate and mostly resolved on their own.

These are not all of the possible side effects of PAPZIMEOS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also report side effects to Precigen, Inc. at 1-855-PGE-NRRP (1-855-743-6777).

Learn about what to expect when starting PAPZIMEOS

Read more about what to expect

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What is PAPZIMEOS?

PAPZIMEOS is a type of immunotherapy used to treat a condition called recurrent respiratory papillomatosis (RRP) in adults.

Important Safety Information

What is the most important information I should know about PAPZIMEOS?

Some people may have a reaction to the shot. Signs and symptoms may include redness, pain, swelling, itching, or warmth where the shot was given. After your first treatment, your healthcare provider will watch you for at least 30 minutes to make sure you're feeling okay.

Please contact your doctor immediately if you develop an infection, the reaction to your shot worsens, or you experience any of the below symptoms, which may indicate a systemic allergic reaction:

  • Difficulty breathing
  • Widespread rash
  • Facial swelling

Thrombotic events (blood clots that block your blood vessels) may occur after your PAPZIMEOS shot. Please notify your doctor immediately if you have the following symptoms:

  • Shortness of breath
  • Chest pain
  • Leg swelling
  • Persistent abdominal pain
  • Severe or persistent headaches
  • Blurred vision

What should I know before taking PAPZIMEOS?

Before taking PAPZIMEOS, tell your healthcare provider about all of your medical conditions, including:

  • If you are pregnant or plan to become pregnant because it is not known if PAPZIMEOS will harm the unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is unknown if PAPZIMEOS is present in breast milk, or how it affects the breastfeeding child or milk production. Talk to your healthcare provider about the best way to feed your baby during treatment with PAPZIMEOS.

What are the most common side effects of PAPZIMEOS?

The most common side effects include:

  • Pain, redness, or swelling where the shot was given
  • Feeling tired
  • Chills
  • Fever
  • Muscle aches
  • Nausea (feeling sick)
  • Headache
  • Increased heart rate
  • Diarrhea
  • Vomiting
  • Sweating a lot

These are not all of the possible side effects of PAPZIMEOS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also report side effects to Precigen, Inc. at 1-855-PGE-NRRP (1-855-743-6777).

Please see full Prescribing Information.

What is PAPZIMEOS?

PAPZIMEOS is a type of immunotherapy used to treat a condition called recurrent respiratory papillomatosis (RRP) in adults.

Important Safety Information

What is the most important information I should know about PAPZIMEOS?

Some people may have a reaction to the shot. Signs and symptoms may include redness, pain, swelling, itching, or warmth where the shot was given. After your first treatment, your healthcare provider will watch you for at least 30 minutes to make sure you're feeling okay.

What is PAPZIMEOS?

PAPZIMEOS is a type of immunotherapy used to treat a condition called recurrent respiratory papillomatosis (RRP) in adults.

Important Safety Information

What is the most important information I should know about PAPZIMEOS?

Some people may have a reaction to the shot. Signs and symptoms may include redness, pain, swelling, itching, or warmth where the shot was given. After your first treatment, your healthcare provider will watch you for at least 30 minutes to make sure you're feeling okay.

Please contact your doctor immediately if you develop an infection, the reaction to your shot worsens, or you experience any of the below symptoms, which may indicate a systemic allergic reaction:

  • Difficulty breathing
  • Widespread rash
  • Facial swelling

Thrombotic events (blood clots that block your blood vessels) may occur after your PAPZIMEOS shot. Please notify your doctor immediately if you have the following symptoms:

  • Shortness of breath
  • Chest pain
  • Leg swelling
  • Persistent abdominal pain
  • Severe or persistent headaches
  • Blurred vision

What should I know before taking PAPZIMEOS?

Before taking PAPZIMEOS, tell your healthcare provider about all of your medical conditions, including:

  • If you are pregnant or plan to become pregnant because it is not known if PAPZIMEOS will harm the unborn baby.
  • If you are breastfeeding or plan to breastfeed. It is unknown if PAPZIMEOS is present in breast milk, or how it affects the breastfeeding child or milk production. Talk to your healthcare provider about the best way to feed your baby during treatment with PAPZIMEOS.

What are the most common side effects of PAPZIMEOS?

The most common side effects include:

  • Pain, redness, or swelling where the shot was given
  • Feeling tired
  • Chills
  • Fever
  • Muscle aches
  • Nausea (feeling sick)
  • Headache
  • Increased heart rate
  • Diarrhea
  • Vomiting
  • Sweating a lot

These are not all of the possible side effects of PAPZIMEOS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. You may also report side effects to Precigen, Inc. at 1-855-PGE-NRRP (1-855-743-6777).

Please see full Prescribing Information.

RRP=recurrent respiratory papillomatosis.